In applying PCR for HIV frozen blood samples from 10 or more years before he saw people who had very few viruses (viral load low) only 10% had developed AIDS, while people who were very much virus (high viral load) tests had developed AIDS and died mostly. Were available until 1995 a series of drugs called Reverse Transcriptase Inhibitors Viral (Retrovir, Videx, HIVID) which, individually or in combination. had a powerful little effect, and also about HIV transient, making delay the onset of AIDS in an infected person maximum 2 years if used in the delayed phase of AIDS death in 1 or 2 years.
This is because the virus can become resistant to these drugs because this changing (mutating) every time they played (replicates), of course, those who have large amounts of virus have higher rates of replication (and resistance) and the prognosis is worse than in the case of having few viruses. He was also with the previous drugs was achieved on average by 10 or dividing by 50 the amount of virus in the blood, which, in someone who had. for example, 300,000 viruses per milliliter, and insufficient to prevent progression to AIDS.
In 1.995-6 appeared, and marketed a series of drugs called protease inhibitors Viral (NORVIR, Invirase, Crixivan), in combination with previous viral load achieved by dividing the 1,000 or more, in some patients manage to disappear blood to these viruses and, keeping the treatment several years, can perhaps completely eliminate the virus from the body.
The experience with two years of use is very good, with mortality reductions of more than 50%, recovery of lost T4 lymphocytes and marked improvement of symptoms of the disease. These treatments are relatively well tolerated and administered by mouth (no need to inject). Although these treatments are very expensive (a protease inhibitor plus two Transcriptase Inhibitors year involving more than 1,300,000 pesetas) in Spain are covered by Social Security and, especially, the lives saved and the savings that occur in hospitalization costs outweigh its economic value.
Tags: Additional Symptoms of AIDS, Aids Factor, AIDS Treatment, Developed AIDS, HIV and AIDS, Prevent progression to AIDS.
